Upon arrival at Kermanshah Airport on Tuesday, Rouhani extended his condolences on behalf of the Iranian nation to the quake-stricken people of Kermanshah.
He also thanked the Iranian people, officials and the countries that had expressed sympathy with the affected people, stressing that the government would try to resolve problems in the shortest time possible.
He will attend an emergency session in Kermanshah.
The quake measuring 7.3 on the Richter scale rattled the border region between Iran and Iraq on Sunday night causing extensive material damage and loss of life.
According to the latest figures, at least 423 people have lost their lives and over 7,000 others sustained injuries in the tremor. Some 12,000 homes have also been completely destroyed in the incident.
A delegation representing Leader of the Islamic Revolution Ayatollah Seyyed Ali Khamenei and Head of Khatam-al Anbiya Construction Headquarters Commander Brigadier Ebadollah Abdollahi visited earthquake-affected areas.
Meanwhile, messages of the condolences continue to pour in from around the world.
The US also offered condolences to the affected Iranian and Iraqi nationals.
"The United States expresses its sincere condolences to all of those affected by the earthquake in Iran and Iraq. We keep the families of those who were killed, and injured, in our thoughts as well as the communities that have suffered damage to homes and property,” said US State Department Spokesperson Heather Nauert on Monday.
Pope Francis, the head of the Roman Catholic Church, also said he was "deeply saddened” by news of the quake and assured all those affected of his "prayerful solidarity.”
Cardinal Pietro Parolin, the Vatican’s secretary of state, that the Pope had sent a telgram to leaders in both Iran and Iraq, praying for the injured and the emergency personnel and civil authorities engaged in rescue efforts.
Iran’s Foreign Minister Mohammad Javad Zarif appreciated the messages of sympathy.
"Heartbreaking images from the earthquake damage and loss of life in Kermanshah (and in Iraq). We are grateful for global expressions of sympathy and offers of assistance. For now, we can manage with our own resources. Many thanks for all offers and we will keep you posted,” he tweeted.